Breast cancer bone mets vaccine

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Vaccines may make the body build an immune response to kill tumor cells. Document the product safety profile in these patients.

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Metastatic breast cancer also called stage IV or advanced breast cancer is not a specific type of breast cancer. It's the most advanced stage of breast cancer. Metastatic breast cancer is breast cancer that has spread beyond the breast and nearby lymph nodes to other organs in the body most often the bones, lungs, liver or brain.

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Treatments can often shrink or slow the growth of bone metastases and can help with any symptoms they cause. But they usually do not make the metastases go away completely. But radiation, chemotherapy and other drugssurgery, and other treatments can often slow cancer growth and help control symptoms.

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Find information and resources for current and returning patients. Learn about clinical trials at MD Anderson and search our database for open studies. The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services.

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Researchers at Fred Hutchinson Cancer Research Center in Seattle may have found a way to essentially smother cancer cells in their sleep, preventing them from ever waking up and forming deadly metastatic tumors. And if you can take away that signaling, you can sensitize them to chemotherapy. Thirty percent of early stagers go on to become metastatic.

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Elucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the rapid rate of progress in both the basic science literature and therapies undergoing clinical trials makes staying abreast with current developments challenging. This review seeks to provide an update on the current state of the science in bone metastasis research and give a snap shot of therapies in clinical trials for bone metastatic cancer.

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Metastatic breast cancer is cancer that originated in the breast and has spread to other organ systems in the body. Women may have metastatic disease at the time of their initial diagnosis or in the months or years following a diagnosis of localized breast cancer. As is true with localized breast cancer, metastasis and its meaning to your health depend on many factors.

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Researchers hope the vaccine combined with trastuzumab can help prevent breast cancer recurrence. Treating breast cancer has long involved addressing two problems: the elimination of cancer cells from the tumor and potential disease recurrence. The key may be to harness the full capabilities of the body's immune system to do both jobs.

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Skeletal metastasis of breast carcinoma is refractory to intensive chemo-radiation therapy and therefore is assumed impossible to cure. Here, we report an advanced case of breast cancer with vertebra-Th7 metastasis that showed complete response to combined treatments with formalin-fixed autologous tumor vaccine AFTVpalliative radiation therapy with 36 Gy, and adjuvant chemotherapy with standardized CEF cyclophosphamide, epirubicin, and 5FUzoledronic acid, and aromatase inhibitors following mastectomy for the breast tumor. The patient has been disease-free for more than 4 years after the mammary surgery and remains well with no evidence of metastasis or local recurrence. Thus, a combination of AFTV, palliative radiation therapy, and adjuvant chemotherapy may be an effective treatment for this devastating disease.


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